Technology Platform - Shanghai Lishan Biopharmaceutical Co., Ltd

Swarming Technology

Swarming is a bacterial motility phenotype characterized by collective cooperative migration behavior, accompanied by adaptive changes in bacterial morphology and metabolic pathways. In the environment of intestinal inflammation, high concentrations of reactive oxygen species, rough interfaces formed by mucosal damage, and high iron ion concentrations caused by bleeding collectively induce the enrichment of facultative anaerobic Swarming bacteria, making them potential biomarkers of intestinal inflammation. Experiments have shown that compared to Swarming phenotype knockout strains, natural Swarming strains are more effective in alleviating intestinal inflammation. At present, Swarming technology has been applied in the treatment of Crohn's disease in the LS-LBP-001 pipeline.

IMicAP Microbial Platform

Lishan Biotech and the Institute of Intelligent Medicine at Fudan University jointly established the "Intelligent Microbiome School Enterprise Joint Laboratory" in 2023. With the knowledge support of the precision medicine knowledge base of the Institute of Intelligent Medicine and the data support of 18 affiliated hospitals, combined with the research results of the company's early participation in the "Human Microbiome Program", they independently developed the Intelligent Microbial Application Platform (IMicAP), obtained national authorized invention patents and international PCT protection, and are committed to becoming a leader in the global "AI+microbiology" sub field.

Indolepropionic Acid Small Molecule Platform

To overcome the bottleneck of high failure rate of candidate drugs due to unpredictable toxicity in traditional drug discovery, Lishan Biotech has developed an innovative platform based on microbial metabolite simulation, dedicated to discovering efficient and low toxicity targets and disease regulators by expanding the chemical space. Based on this platform, Lishan Biotech's LS-SM-001 pipeline has successfully developed a class of weak agonists for pregnane X receptors (PXR), which can be co activated by L-tryptophan metabolites indole and indole-3-propionic acid. The team further optimized the lead compound based on the pharmacophore characteristics of relevant metabolites and PXR ligand binding domains, as well as the ideal PXR interaction spectrum in cells. In acute and chronic toxicity experiments, the compound did not cause any clinical toxicity and effectively alleviated drug-induced colitis in transgenic mouse models expressing human PXR.

Delay Photography Incubator

Delay Photography Incubator is a high-end scientific research equipment that integrates constant temperature and humidity cultivation, high-definition image capture, and dynamic observation of bacteria. Equipped with high-precision environmental control and high-definition image acquisition capabilities, it can achieve uninterrupted and continuous observation of the entire process of bacterial growth. Users can flexibly adjust photography parameters and temperature and humidity conditions through the device panel to meet diverse bacterial cultivation and photography analysis needs. This device supports simultaneous shooting of up to 9 90mm culture dishes and is compatible with multiple other sizes, demonstrating excellent adaptability and high-throughput shooting capabilities. With excellent stability, precise temperature and humidity control, and highly integrated shooting system, this equipment provides efficient and reliable cultivation and image recording solutions for microbial research.